Email: [email protected] precursor transplantation provides a potential therapy for brain disorders. We found that transplanted glial precursor cells derived from embryonic neural stem cells (NSCs) into the adult somatosensory cortex could develop into astrocytes that were able to survive for more than a year, nearly as long as the life span of mice, and express molecular and morphological features of mature cortical astrocytes.Before its clinical application, experimental evidence needs to indicate that engrafted glial cells are functionally incorporated into the existing circuits and become essential partners of neurons for executing fundamental brain functions. Therefore, how transplanted astrocytes are incorporated into the host neural circuits and whether these astrocytes can eventually execute basic brain functions like sensory information processing require further in vivo investigation. We also found that engrafted astrocytes in the adult sensory cortex responded with Ca responses in engrafted astrocytes were dependent on the functional expression of nicotinic acetylcholine receptors (n Ach Rs) and the formation of synapse-like contacts with host cholinergic afferents from the basal forebrain.Escolhendo entrar neste site, você está afirmando sob juramento e penalidades de perjúrio ao Artigo do título 28 U. Earth Cam takes you on a virtual tour of the most visited spot in New York City: Times Square!
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