Non sedating antihistimine

Antihistamines are classified into two groups – the first-generation (“sedating”) and second-generation (“non-sedating”).Sedating antihistamines cause sedation as they are highly lipid soluble and readily cross the blood brain barrier.With non-sedating antihistamines, it is no longer necessary to choose between being free from allergy symptoms and going about your daily business; it is possible to do both.Histamine is a naturally occurring nitrogen-based chemical that is essential to localized immune responses and various physiological bodily functions, including sleep, sexual activity and much more.Desloratadine inhibited histamine release from human mast cells in vitro.Results of a radiolabeled tissue distribution study in rats and a radioligand H1-receptor binding study in guinea pigs showed that desloratadine did not readily cross the blood brain barrier. Dosing: Oral: Children: 6-11 months: 1 mg once daily 12 months to 5 years: 1.25 mg once daily 6-11 years: 2.5 mg once daily Children /= 12 years and Adults: 5 mg once daily Supplied Syrup (Clarinex®): 0.5 mg/m L (480 m L) [bubble gum flavor] Tablet (Clarinex®): 5 mg Tablet, orally-disintegrating (Clarinex® Redi Tabs®): 5 mg [contains phenylalanine 1.75 mg/tablet] Adult (usual) Chronic idiopathic urticaria: 60 mg orally twice daily.

Sedating antihistamines also have significant antimuscarinic activity and should be used with caution in patients with prostatic hypertrophy, urinary retention and angle-closure glaucoma.So concludes a new study published in the current issue of Journal of Allergy and Clinical Immunology in which researchers compared 18 previous trials investigating antihistamine-caused sedation levels in 1,500 people between ages 8 and 81.Most of the studies reviewed used doses that were twice the recommended amount -- 50 milligrams -- of diphenhydramine, the active ingredient in Benadryl and other first-generation "sedating" allergy medications."In some studies we reviewed, some people actually experienced more sedation with the newer, nonsedating formulas than with the older, sedating products.Non-sedating antihistamines are helping to improve the lives of countless people who suffer from the symptoms of serious allergic reactions.Although antihistamines are by no means a recent discovery, the development of the new class of non-sedating antihistamines allows many more allergy sufferers to benefit from the therapeutic effects of the drugs without experiencing their annoying and often unmanageable side effects such as sedation, which is a condition or state in which one feels overly calm and serene; it is akin to being tranquillized.

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